Profile of Nahum Sonenberg.
نویسنده
چکیده
Five years after the final shots of World War II rang out, a child and his father stood on the coast of the Mediterranean Sea. From their vantage point in a cemetery in the town of Jaffa, Israel, the boy gazed across the sea and envisioned stepping onto the sands of a distant shore. He pointed to the horizon and asked his father what lay beyond. “I remember my father said, ‘There is America, the country where everything is possible,’” says Nahum Sonenberg, the Gilman Cheney Professor of Biochemistry at McGill University in Montreal. Sonenberg, elected as a foreign associate to the National Academy of Sciences in 2015, has spent nearly five decades looking beyond the horizon to map unexplored territory in molecular biology. His research has uncovered the cellular control knobs of protein synthesis and revealed how this process drifts off-course in cancer, obesity, diabetes, and neurological diseases. His achievements have garnered numerous honors. Sonenberg is a fellow of the Royal Society of London and Canada, Foreign Member of the American Academy of Arts and Sciences and the American Association for the Advancement of Science, Associate Member of European Molecular Biology Organization, and an Officer of the Order of Canada. He has received numerous prizes in the biological sciences, including the Lewis S. Rosenstiel Award for Distinguished Work in Basic Medical Science, the Wolf Prize, and the Gairdner Foundation International Award.
منابع مشابه
Antiviral effect of the mammalian translation initiation factor 2 kinase GCN2 against RNA viruses
Juan J Berlanga, Iván Ventoso, Heather P Harding, Jing Deng, David Ron, Nahum Sonenberg, Luis Carrasco and César de Haro* Centro de Biologı́a Molecular ‘Severo Ochoa’, CSIC-UAM, Facultad de Ciencias, Cantoblanco, Universidad Autónoma de Madrid, Madrid, Spain; Skirball Institute, Departments of Medicine and Cell Biology and the Kaplan Cancer Center, New York University School of Medicine, New Yor...
متن کاملDistinctive tRNA Repertoires in Proliferating versus Differentiating Cells
Transfer RNAs (tRNAs) deliver amino acids to the ribosome during mRNA translation. Gingold et al. now provide evidence that alterations in the cellular tRNA repertoire are tightly coordinated with changes in mRNA expression. These changes in the tRNA repertoire dictate translational programs that distinguish differentiating from proliferating cells.
متن کاملTranslational Control by the Eukaryotic Ribosome
The ribosome plays a universally conserved role in catalyzing protein synthesis. Kondrashov et al. (2011) now provide evidence that the loss of function of ribosomal protein L38 in mice leads to a selective reduction in the translation of Hox mRNAs, thus suggesting that ribosomal proteins play a critical role during embryonic development.
متن کاملRegulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets
Translational control in eukaryotic cells is critical for gene regulation during nutrient deprivation and stress, development and differentiation, nervous system function, aging, and disease. We describe recent advances in our understanding of the molecular structures and biochemical functions of the translation initiation machinery and summarize key strategies that mediate general or gene-spec...
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ورودعنوان ژورنال:
- Proceedings of the National Academy of Sciences of the United States of America
دوره 114 34 شماره
صفحات -
تاریخ انتشار 2017